10.22376/ijpbs.2019.10.1.p1-12 Volume 11 Issue 1 2020 (January-March) The plants are a vast resource of phytoconstituents which could treat different diseases. The methanolic extract of lessThan i greaterThan Physalis minima lessThan /i greaterThan fruits was screened for anti-diabetic activity. The literature survey revealed that these studies were not reported earlier. So, the present research study was aimed to reveal the anti-diabetic activity of lessThan i greaterThan Physalis minima lessThan /i greaterThan fruits. The results concluded that the extract possess anti-diabetic activity. The study showed good significance in repair of damaged β-cells in diabetic lessThan i greaterThan Physalis minima lessThan /i greaterThan fed rats, when compared to diabetic control animals. Ithas been concluded that lessThan i greaterThan Physalis minima lessThan /i greaterThan extract showed hypoglycaemic activity on prolonged treatment and is also regenerating β- cells and so it could be used in the treatment of diabetes mellitus. K. SUNITHA AND A. SRINIVAS NAYAK Anti-diabetic, Methanolic extract, Physalis minima, hypoglycaemic activity, Diabetes mellitus. 58-62