10.22376/ijpbs.2019.10.1.p1-12 Volume 11 Issue 1 2020 (January-March) lessThan i greaterThan Holoptelea integrifolia lessThan /i greaterThan (Ulmaceae) is a versatile medicinal plant encompassing a wide range of pharmacological properties. The present study is aimed at assessment of anti-bacterial activities of bark and leaf phytochemicals against the common oral bacterial pathogens namely lessThan i greaterThan Staphylococcus aureus, Streptococcus oralis, Streptococcus mutans, Streptococcus gordonii, Lactobacillus brevis lessThan /i greaterThan and lessThan i greaterThan Lactobacillus casei lessThan /i greaterThan . Bark and leaf dried powder samples were Soxhlet fractionated with solvents viz. petroleum-ether, chloroform, absolute-ethanol, 80%-methanol and distilled-water. Antibacterial potentials of the fractionated extracts against oral pathogens were evaluated with respect to zone of inhibition, MIC, MBC and IC lessThan sub greaterThan 50 lessThan /sub greaterThan values whereas antioxidant activities were assessed against ABTS lessThan sup greaterThan + lessThan /sup greaterThan and DPPH free radicals. The results demonstrated significantly higher antibacterial activity in bark ethanolic extracts (HiBE) towards every tested oral bacterial pathogen as established by its greater zone of inhibition and lowest MIC, MBC and IC lessThan sub greaterThan 50 lessThan /sub greaterThan values. HiBE most potent antibacterial action against lessThan i greaterThan L. casei lessThan /i greaterThan followed by lessThan i greaterThan L. brevis lessThan /i greaterThan , lessThan i greaterThan S. mutans lessThan /i greaterThan , lessThan i greaterThan S. aureus, S. gordonii and S. oralis lessThan /i greaterThan HiBE showed remarkable ABTS lessThan sup greaterThan + lessThan /sup greaterThan and DPPH free radicals scavenging activities with abundance of phenolics, flavanoids and tannins. Therefore, the present study ascertains lessThan i greaterThan H. integrifolia lessThan /i greaterThan bark extracts as a commendable natural remedy for treating oral-dental infections. SAVITA PETWAL, MADHURI KAUSHISH LILY AND KOUSHALYA DANGWAL Antibacterial activity; antioxidant; H. integrifolia bark and leaves; oral bacterial pathogens; polyphenols; oral diseases 43-50