10.22376/ijpbs.2019.10.1.p1-12 Volume 10 Issue 2 2019 (April-June) This study was designed to evaluate thyroid status in pregnant women as routine antenatal checkup as suggested by the Health and Family Welfare department, Government of India. The present study was carried out to determine the incidence of Hypothyroidism among pregnant women in tertiary care centre at GGH, Guntur, AP. 240 subjects were selected for the study after careful screening for thyroid disorders, PIH, GDM or other endocrine diseases. Their venous blood samples were analysed for TSH, Total T3 and Total T4. The number of subjects in each trimester were 80. The results showed that 1/3 lessThan sup greaterThan rd lessThan /sup greaterThan of the study group fall in the category of subclinical hypothyroid when S.TSH of greaterThan 2.5µIU/ml was considered as significant rise. There was significant correlation of mean TSH of SCH and Euthyroid group with a P value lessThan 0.001. Trimester-wise mean TSH values of SCH & Euthyroid showed significant difference (ANOVA)P value lessThan 0.00001. 2-tailed paired 't' test showed significant correlation of mean TSH in 1 lessThan sup greaterThan st lessThan /sup greaterThan &2 lessThan sup greaterThan nd lessThan /sup greaterThan trimester P value lessThan 0.002 but significance was negligible in 2 lessThan sup greaterThan nd lessThan /sup greaterThan &3 lessThan sup greaterThan rd lessThan /sup greaterThan trimesters. There was conclusive evidence to prove that pregnant women were prone to develop hypothyroidism can prove detrimental to maternal and fetal health. Thyroid status needs to be evaluated in all pregnant women irrespective of risk factors. DR. V. ARUNA Pregnancy, Thyroid Stimulating Hormone, Subclinical Hypothyroidism 54-60