10.22376/ijpbs.2019.10.1.p1-12 Volume 10 Issue 1 2019 (January - March) The development of Nanoparticles loaded with drug formulations has provided the opportunities to treat challenging diseases like cancer, AIDS and many other. Nanoparticles stacked with drug contrasts in size over a range from 100 to 500 nm. By the alteration of size, surface charge and materials used, the nanoparticles can be derived into smart systems, enclosing therapeutic and imaging agents and also as bearing stealth property. Further, these systems can release drug to identified tissues and provide regulated release therapy. This targeted and controlled drug delivery increase patient's compliance with less recurrent dosing and decreases the drug related toxicity. Nanotechnology has proven favourable in the treatment of cancer, also providing advancement in diagnostic testing. Docetaxel loaded nanoparticles has potential role for the treatment of various cancers and also it has gained a lot of attention towards immunotherapy by enhancing its immune response in presence adjuvant like to toll like ligand 4 (TLR-4) to enhance DC maturation. In this regard, we have chosen polypyrrole nanoparticles loaded with docetaxel has tendency that extends to a level of DC maturation through photo response as well as adjuvant. Primarily, we characterized nanoparticles hydrodynamic size and loading of adjuvant presence through DLS and FTIR. Further, stability of nano adjuvant particles confirmed through DLS and found to be more than 3 months. The resultant Nano samples exhibited biocompatibility on B16F10 cells in absence of adjuvant and antigen at high concentration beyond the physiological range showing toxicity. In addition to that, these Nano samples exhibited little extendable DC maturation which is sufficient to treat cancer as well as extendable potential range also observed in CV studies. Our results reveal that future vaccine models for treatment of cancer.  M. CHANDAN KUMAR, V.SRIDEVI , D.V.S.GIRIS , J.ASHOK AND D.SRI VIVEK DORA Nanoparticles, Fluorescence, Drug loading capacity, DC Maturation, Bio-computability, Immunotherapy, Drug Delivery, Cancer treatment. 83-99