10.22376/ijpbs.2019.10.1.p1-12 Volume 10 Issue 1 2019 (January - March) lessThan i greaterThan Rasamanikya lessThan /i greaterThan is a mineral formulation mentioned in the chapter on lessThan i greaterThan Shwitraroga lessThan /i greaterThan (Vitiligo) lessThan i greaterThan lessThan /i greaterThan in lessThan i greaterThan Rasendrasara Sangraha lessThan /i greaterThan , a classical Ayurveda text lessThan i greaterThan . lessThan /i greaterThan Another classical text, lessThan i greaterThan Rasatangini, lessThan /i greaterThan has also stressed upon the efficacy of lessThan i greaterThan Rasamanikya lessThan /i greaterThan in lessThan i greaterThan Kushtharoga lessThan /i greaterThan (skin disorders). However, the fact that lessThan i greaterThan Rasamanikya lessThan /i greaterThan is prepared from lessThan i greaterThan Hartala lessThan /i greaterThan , ie. Orpiment (an arsenic sulfide mineral), is fear evoking among some medical practioners and thus a probable cause for its marginal use in therapeutics. The present review explores lessThan i greaterThan Rasamanikya lessThan /i greaterThan from all the aspects. To start with, the present review first provides an insight into the pharmaceutical and analytical aspect of lessThan i greaterThan Rasamanikya. lessThan /i greaterThan Thereafter, the pre-clinical studies that include the in-vitro antimicrobial activity study and the in-vivo toxicity studies conducted on lessThan i greaterThan Rasamanikya lessThan /i greaterThan have been discussed. And lastly, the clinical aspects of lessThan i greaterThan Rasamanikya lessThan /i greaterThan have also been enlightened in this review. The classical and authoritative lessThan i greaterThan Ayurvedic lessThan /i greaterThan lessThan i greaterThan Rasashastra lessThan /i greaterThan literature, the scientific research papers and the relevant information on the internet have been used in this review. The present review also provides clues for further scientific studies on lessThan i greaterThan Rasamanikya. lessThan /i greaterThan PRITAM C. VAITY, AND VAISHALI M. KHOBRAGADE Ayurveda, Rasamanikya, Anti-microbial effect, Toxicity study, Skin disorders 49-54