10.22376/ijpbs.2019.10.1.p1-12 Volume 9 Issue 4 2018 (October - December) The aim of the present study was to observe the antidiabetic and hepatoprotective activities of ethanolic extract of lessThan i greaterThan Eriobotrya japonica lessThan /i greaterThan fruits in streptozotocin induced diabetic rats. The phytochemical screening of the plant was also done. The animals were divided into five groups. Normal Control group received only the vehicle. Toxic group included those animals in which diabetes was induced by streptozotocin. The 3 lessThan sup greaterThan rd lessThan /sup greaterThan group of animals received streptozotocin and standard antidiabetic drug-glibenclamide. The 4 lessThan sup greaterThan th lessThan /sup greaterThan group included those diabetic animals which received 50 mg/kg b.w dose of fruits of lessThan i greaterThan Eriobotrya japonica lessThan /i greaterThan extract. The 5 lessThan sup greaterThan th lessThan /sup greaterThan group of animals included those diabetic animals which received 100 mg/kg b.w of the plant extract. The biochemical parameters that were evaluated includes blood glucose levels and liver function tests. At the end, the animals were sacrificed and histopathology of pancreas and liver was also done. The results showed significant decrease in blood glucose levels, when treated with two different doses of the plant extract. There was reduction in liver function tests also in animals .The extract of lessThan i greaterThan Eriobotrya japonica lessThan /i greaterThan fruits have shown significant antidiabetic and hepatoprotective activities attributed to its antidiabetic and hepatoprotective potential. SABEEHA SHAFI AND NAHIDA TABASSUM Eriobotrya japonica fruits, anti-diabetic, hepatoprotective, streptozotocin 82-91