<?xml version="1.0" encoding="utf-8"?>
<Journal>
<Journal-Info>
<name>International Journal of Pharma and Bio Sciences</name>
<website>ijpbs.net</website>
<email>editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com</email>
</Journal-Info>
<article>
<article-id pub-id-type='other'>10.22376/ijpbs.2019.10.1.p1-12</article-id>
<issue_number>Volume 9 Issue 4</issue_number>
<issue_period>2018 (October - December)</issue_period>
<title><b>Purification and therapeutic potentialities of Phycocyanin in spirulina platensis</b> </title>
<abstract>The aim of the present study is to purify and to find out the therapeutic potentialities of Phycocyanin(pc) present in  lessThan i greaterThan Spirulinaplatensis.  lessThan /i greaterThan Novel method for purifying the phycocyanin of  lessThan i greaterThan S.platensis lessThan /i greaterThan was developed by freezing and thawing method. Antimicrobial assay was studied by agar well diffusion assay. The stability of the extracted pc was also confirmed by comparing its antioxidants using Ferric Reducing Antioxidant Potential (FRAP) and 2, 2'-azino-bis 3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assay. Effect of aqueous extract of  lessThan i greaterThan S. platensis lessThan /i greaterThan was investigated on blood platelet aggregation in terms of prothrombin time (PT) and activated partial thromboplastin time (APTT).Two subunits of pc namely α-pc (15.6 kDa) and β-pc (23.4 kDa) were found to remain from the original mixtures based on SDS-PAGE. The results showed that all  lessThan i greaterThan S. platensis  lessThan /i greaterThan extracts exhibited great potential antibacterial activities against four bacterial and fungal strains. The study revealed that  lessThan i greaterThan S. platensis  lessThan /i greaterThan has potent bio compatibilities. The results of the study confirm that the pc can be used as drug, with lot of therapeutic ventures. All these studies confirm the therapeutic ventures of this compound as potent agent.</abstract>
<authors>NEHA PURI, MANAS MATHUR, ANKITA ANAND, ASHISH SHARMA
AND AJIT KUMAR SWAMI
</authors>
<keywords>SDS-PAGE; Therapeutic ventures: Phycocyanin</keywords>
<pages>57-68</pages>
</article>
</Journal>
