10.22376/ijpbs.2019.10.1.p1-12 Volume 9 Issue 3 2018 (July-September) This research aims to study water quality, heavy metal concentrations in water, sediment, and lessThan i greaterThan Channastriata lessThan /i greaterThan ; and the cytotoxicity of lessThan i greaterThan C. striata lessThan /i greaterThan from a domestic waste water canal compared with a non-affected area. The heavy metal concentrations (Pb, Cd, Cr, Cu, Fe, Mn, Ni and Zn) in water, sediment and lessThan i greaterThan C. striata lessThan /i greaterThan were analyzed by Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES), and chromosomal aberrations were analyzed directly from kidney cells. The Ni concentration in the water was higher than the standard limits while other heavy metal concentrations in the sediment and lessThan i greaterThan C. striata lessThan /i greaterThan were lower than the standard. The diploid chromosome number of lessThan i greaterThan C. striata lessThan /i greaterThan was 2 lessThan i greaterThan n lessThan /i greaterThan =42 in samples taken frombothareas.Fivetypes of chromosomal aberrations of lessThan i greaterThan C. striata lessThan /i greaterThan included Single Chromatid Break (SCB), Single Chromatid Gap (SCG), Centromere Gap (CG), Deletion (D) and Fragmentation (F) at both areas. In the 300 cells evaluated, 98 chromosomal aberrations were found in 59 cells and the percentage of chromosomal aberrations was 19.6%. The percentage of chromosomal aberrations of lessThan i greaterThan C. striata lessThan /i greaterThan in the domestic waste water canal was higher than that in the non-affected area. The most common chromosomalaberration in lessThan i greaterThan C. striata lessThan /i greaterThan samples from the domestic waste water canal was SCG. BUNDIT TENGJAROENKUL AND LAMYAI NEERATANAPHAN heavy metal; domestic waste water; cytotoxicity; Channastriata 297-307