10.22376/ijpbs.2019.10.1.p1-12 Volume 9 Issue 3 2018 (July-September) In this study methanolic extract of rhizomes of lessThan i greaterThan Hedychium coronarium lessThan /i greaterThan ( lessThan i greaterThan H.coronarium lessThan /i greaterThan ) belonging to family Zingiberaceae was evaluated for antipyretic and antimicrobial activity by determining its minimum inhibitory concentration MIC (by checker board method) and zone of inhibition (by cup plate method). This study was designed to evaluate the antimicrobial efficacy of the methanolic extract of the rhizomes of lessThan i greaterThan H. coronarium lessThan /i greaterThan against various diarrhea and dysentery causing drug resistant microorganisms isolated from patients admitted in hospitals. It was evident from the results that the extract was highly active against lessThan i greaterThan Shigella boydii lessThan /i greaterThan , lessThan i greaterThan Shigella. soneii lessThan /i greaterThan , lessThan i greaterThan Shigella flexneri, Vibrio cholera, E. coli, S. aureus and K. pneumoniae lessThan /i greaterThan . The result of determination of zone of inhibition was compared with that of standard drug (Ciprofloxacin). This study has pointed that the extract was highly active against lessThan i greaterThan Shigella boydii lessThan /i greaterThan , lessThan i greaterThan Sh. soneii lessThan /i greaterThan , lessThan i greaterThan Shigella flexneri, Vibrio cholera lessThan /i greaterThan , lessThan i greaterThan E. coli lessThan /i greaterThan , lessThan i greaterThan S. aureus lessThan /i greaterThan and lessThan i greaterThan K. pneumoniae lessThan /i greaterThan . The finding of this study further reinforces the importance of lessThan i greaterThan H. coronarium lessThan /i greaterThan rhizomes in traditional healthcare practice. Further investigation is underway to isolate and purify the bioactive antimicrobial principles for potential development into generic antimicrobial agent RITU ARORA AND AVIJIT MAZUMDER H. coronarium,Antipyretic, Gram positive, 142-146