International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 9 Issue 2
2018 (April-June)
Biochemical determinants of the severity of Haemolysis in patients with G6PD deficiency
Glucose-6-phosphate dehydrogenase (G6PD) deficiency represents a major health problem for Iraqis, especially during the fava bean harvesting season. This study aimed to assess the clinical and biochemical characteristics as predictors of severe haemolysis among these patients. A total of 98 patients with G6PD deficiency were recruited from the Emergency Department of Al-Karama Teaching Hospital. Patients were classified into either non-severe or severe haemolysis groups based on their haemoglobin level at the time of admission. Of the 98 cases, 48 (48.98%) were diagnosed as severe haemolysis. Logistic regression revealed that younger age (expand AOR AOR: 0.77, p lessThan 0.05), living in rural region (AOR: 3.14, p lessThan 0.01), ingesting fresh fava beans (AOR: 1.99, p lessThan 0.01), history of frequent haemolysis (AOR: 2.73, p lessThan 0.01), jaundice (AOR: 1.55, p lessThan 0.05), lethargy (AOR: 1.69, p lessThan 0.05), high total serum bilirubin (AOR: 1.34, p lessThan 0.05), high lactate dehydrogenase (AOR: 1.42, p lessThan 0.05), high reticulocyte count (AOR: 2.31, p lessThan 0.01), and deep dark coloured urine at admission (AOR: 3.17, p lessThan 0.001) were predictors of severe haemolysis. Severe haemolysis among G6PD patients can be predicted by several clinical and biochemical factors.
ZEENA ABDUL ILAH, SAHAR ABDUL WAHAB AL-SHABAN
severity of haemolysis, G6PD, predictors, Iraqi patients
358-364