10.22376/ijpbs.2019.10.1.p1-12 Volume 9 Issue 1 2018 (January-March) The purpose of the present study was to investigate the methanolic extract of lessThan i greaterThan Bruguiera lessThan /i greaterThan lessThan i greaterThan gymnorrhiza lessThan /i greaterThan and lessThan i greaterThan Aegialitis rotundifolia lessThan /i greaterThan for their cytotoxic and apoptotic induction activities. The cytotoxic activity was evaluated by MTT assay against hepG2 and MCF7 Cell lines. Induction of Apoptosis was carried hepG2 cell line. Morphological changes and DNA fragmentation were found up on incubation with extract. Both the plant extracts showed significant cytotoxic activity against hepG2 and MCF7 cell lines and the concentration required for 50% cell death was 77.29 µg/ml, and 99 µg/ml for lessThan i greaterThan Bruguiera gymnorrhiz lessThan /i greaterThan a; 97.77 µg/ml and 165.34 µg/ml for lessThan i greaterThan Aegialitis rotundifolia lessThan /i greaterThan against hepG2 and MCF7 cell lines respectively. Thus from the present investigation it can be concluded that the methanolic extract of lessThan i greaterThan Bruguiera gymnorrhiza lessThan /i greaterThan and lessThan i greaterThan Aegialitis rotundifolia lessThan /i greaterThan exhibit both Apoptosis induction and Cytotoxic activities. A.R.K REDDY AND J. RATNA GRACE Apoptosis, MTT assay, Cytotoxicity, DNA Fragmentation, Mangrove. 315-322