10.22376/ijpbs.2019.10.1.p1-12 Volume 9 Issue 1 2018 (January-March) The present study was undertaken to evaluate the protective effect of lectin purified from lessThan i greaterThan Morus nigra lessThan /i greaterThan against lipopolysaccharide induced oxidative stress in experimental rats. Exposure of rats to lipopolysaccharide caused a significant increase in the lipid peroxidation level along with corresponding decrease in the reduced glutathione and various antioxidant enzymes in liver.and increase in serum: APL and transaminases activities. Supplementation of purified lectin of lessThan i greaterThan Morus nigra lessThan /i greaterThan to lipopolysaccharide decrease in the serum the activities of AST, ALT and APL along with increase in liver GSH level and various antioxidant enzymes: glutathione peroxidase (GSH-Px), glutathione –S-transferase (GST) and catalase however the level of lipid peroxidation was increased in liver. Furthermore, no histological alterations were observed in the liver of lectin of lessThan i greaterThan Morus nigra lessThan /i greaterThan . The results clearly demonstrate the protective role of new lectin purified from lessThan i greaterThan Morus nigra lessThan /i greaterThan against LPS induced inflammatory liver in rats. AHLEM BAHI AND YOUCEF NECIB Antioxidant enzymes, lectin, lipopolysaccharide, anti-inflammatory activity, Morus nigra. 66-72