10.22376/ijpbs.2019.10.1.p1-12 Volume 9 Issue 1 2018 (January-March) Piperazines are a wide class of chemical compounds with numerous important pharmacological properties. An ease and highly efficient synthetic protocol was accomplished for the synthesis of novel lessThan i greaterThan N lessThan /i greaterThan , lessThan i greaterThan N lessThan /i greaterThan '-disubstituted lessThan i greaterThan β lessThan /i greaterThan -branched nitroolefin containing new piperazine molecular architectures. As the Michael addition of alkyl anion equivalents to simple nitro olefins proceeds in a non-stereo selective way, the lofty stereo selectivity requires heteroatom substituent on the lessThan i greaterThan β lessThan /i greaterThan - position of the nitronated anion intermediates. Eleven new lessThan i greaterThan N lessThan /i greaterThan , lessThan i greaterThan N lessThan /i greaterThan '-disubstituted lessThan i greaterThan β lessThan /i greaterThan -branched nitroolefin piperazine derivatives were synthesized using this technique, purity of compounds was ascertained by melting point and thin-layer chromatography. All Compounds have been characterized by lessThan sup greaterThan 1 lessThan /sup greaterThan H – lessThan sup greaterThan 13 lessThan /sup greaterThan C NMR. Among the synthesized new compound lessThan b greaterThan 10g lessThan /b greaterThan 1,4-bis((E)-3-(3,4-dimethoxyphenyl)-2-nitroallyl)piperazine exhibited potent antimicrobial activities by both Disc diffusion and broth dilution method. The synthesized compounds were subjected to molecular docking studies through commercial software using Discovery Studio 4.0. Furtherly the pharmacokinetics properties were studied by ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity). DMol lessThan sup greaterThan 3 lessThan /sup greaterThan Properties and B3LYP functions were executed in DFT (Density Functional Theory studies) DS 4.0. The compound 10g was found to be a potent and safe by ADMET studies. The compound10g could be proposed for further in vitro and in vivo studies. J.IRSHAD AHAMED AND K. S. MEENA 1, 4-disubstituted piperazines synthesis, molecular docking, Gram(+) bacteria, Gram(-) bacteria, Disc Diffusion Method, MIC (μg/ml). 1-15