10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 4 2017 (October - December) The main aim of the present work is to formulate and evaluate anophthalmic drug delivery system of bromfenac sodium using suitable gelling polymers by cooling technique. For elucidating the effect of formulation factors of press coated tablets a 3 lessThan sup greaterThan 2 lessThan /sup greaterThan full factorial design was employed. The effect of two factors, amount of gelling agent (X lessThan sub greaterThan 1 lessThan /sub greaterThan ) and amount of viscosity enhancer (X lessThan sub greaterThan 2 lessThan /sub greaterThan ) as independent variables were studied on dependent variables Y lessThan sub greaterThan 1 lessThan /sub greaterThan (gelling capaciy), Y lessThan sub greaterThan 2 lessThan /sub greaterThan (gelation temperature) and Y lessThan sub greaterThan 3 lessThan /sub greaterThan (Cumulative % drug release). The prepared lessThan i greaterThan in situ lessThan /i greaterThan gelwere evaluated for clarity, pH, gelling capacity, gelation temperature, viscosity, drug content, lessThan i greaterThan in vitro lessThan /i greaterThan drug release and kinetics studies.All the formulations were clear, transparent and yellow.The pH of the formulations ranges from 7.01-7.34 which is an acceptable range when compared with the eye pH of 7.4.Gelation temperature was between 37-43.5°C for all the formulations.The gelling capacity of the formulations was found to be between 4-10 hr. All the formulations follow pseudo plastic behaviour (shear thinning systems). This property is very useful during the inter blinking of the eye. A shear thinning ophthalmic system does not cause any inconvenience to the patient.Drug content of all the formulations was in between 95.13-98.55 %. lessThan i greaterThan In vitro lessThan /i greaterThan drug release of the formulations was decreased when the amount of gelling agent and viscosity enhancer was increased.The optimum formulation consisting of bromfenac (90mg), poloxamer 188 (15g) and HPMC E5 (1.75g) exhibited gelling capacity of 7.12 h, gelling temperature of 37.02 °C and cumulative % drug release of 98.19 % in 12 h. Bromfenac sodium lessThan i greaterThan in situ lessThan /i greaterThan gel exhibited biphasic release profile obeying zero order release kinetics following non-Fickian diffusion mechanism. JAKIRHUSSAINMUSTAQ SHAIK , MOUNIKA VEGESNA , CHANDANA ROJA , SWATHI PUTTA , BHAVANI BODDEDA Bromfenac sodium, Factorial design, In situ gel, Ocular retention, Rheology, thermo-sensitive. 200-211