10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 4 2017 (October - December) In this study, we developed encapsulating doxorubicin (DOX) drug loaded starch coated lessThan i greaterThan Hygrophila auriculata lessThan /i greaterThan L mediated gold nanoparticles lessThan b greaterThan ( lessThan /b greaterThan H-AuNPs) [DOX loaded starch coated-H-AuNPs]. H-AuNPs were characterized by UV-Visible spectrophotometer, XRD, TEM. The DOX-loaded starch coated-H-AuNPs was evaluated by particle size, surface charge, entrapment efficacy, and effect of pH in drug release profile. Additionally, drug entrapment efficacy (EE) was up to 43%; DOX-starch-H-AuNPs showed a pH-responsive drug release in vitro. The DOX release was nearly 79% at pH 5.4 and 68% at pH 7.4.The current work proves the potential of pharmacology that involves a fusion of advanced techniques from nanoscience to develop the biology and used in the fields of drug delivery. PRADIPTA DAS AND UMESH KUMAR PARIDA Hygrophila auriculata L, AuNPs, starch, Doxorubicin, Drug delivery 307-313