10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 4 2017 (October - December) Bacteraemia and septicaemia are a major health problem, which leads to high morbidity and mortality of patients. Timely diagnosis and appropriate medication will be the best way to save the lives of affected ones. The aim of the present study was to determine the bacterial profile of suspected bacteraemia cases and antibiotic susceptibility pattern of ESKAPE pathogens. This is a retrospective study of 3684 blood samples collected from clinically suspected cases of bacteraemia, over a period of two years (April 2015 to March 2017). The isolates were identified by conventional biochemical tests and antimicrobial susceptibility testing by CLSI guidelines. Positive cultures were obtained in 240 (6.5%) cases of which ESKAPE organisms accounted for 66% of cases with lessThan i greaterThan Pseudomonasaeruginosa lessThan /i greaterThan 34% lessThan i greaterThan (81) lessThan /i greaterThan predominance, non ESKAPE organisms accounted were 34% of cases with lessThan i greaterThan E. coli lessThan /i greaterThan 15% lessThan i greaterThan (36) lessThan /i greaterThan predominance and one fungal isolates. Antibiotic resistant pattern among ESKAPE pathogens were, among lessThan i greaterThan Enterococcus faecium lessThan /i greaterThan only one was resistant to vancomycin, among lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan Methicillin esistant lessThan i greaterThan taphylococcus aureus lessThan /i greaterThan resistant was observed. lessThan i greaterThan Klebsiella lessThan /i greaterThan spp resistant to piperacillin tazobactam and cefaperazone sulbactum, lessThan i greaterThan Acinetobacter baumannii lessThan /i greaterThan and lessThan i greaterThan P. aeruginosa lessThan /i greaterThan ciprofloxacin showed highest activity followed by cefoperazone and sulbactum. lessThan i greaterThan Enterobacter lessThan /i greaterThan spp showed no resistance. This study highlights the health crisis & emergence of ESKAPE pathogens as predominant cause of bacteraemia. It is necessary that the last remaining antimicrobial agents be protected via intellectual choice and ameliorated infection control. Prescription of the most appropriate antibiotics at the right dose and period will consistently improve the sick and decrease the appearance of antibiotic resistance. SUGANTHA VALLI.M , S.S.M.UMAMAGESWARI AND M.KALYANI Bacteraemia, Septicaemia, Febrile patients, Antimicrobial susceptibility pattern, ESKAPE pathogens. 65-69