10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 2 2017 (April - June) lessThan i greaterThan Phaleria macrocarpa lessThan /i greaterThan is an Indonesian medicinal plant which has been known for its various uses. The present study aims to evaluate efficacy, antioxidant activity and cytotoxicity of DLBS1433, a bioactive fraction obtained from lessThan i greaterThan P. macrocarpa lessThan /i greaterThan , as a hepatoprotective agent in ethanol-induced liver damage in lessThan i greaterThan Rattus norvegicus lessThan /i greaterThan . Ethanol was administered to all rats (5 g/kg/day, 20% v/v) for 4 w and followed by treatment with DLBS1433-60 and DLBS1433-90 for 1 w, respectively. lessThan i greaterThan Curcuma domestica lessThan /i greaterThan extract treatment group was used as a comparison. Blood biochemical parameters, which are the markers of liver function including alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin and gamma-glutamyl transferase (GGT), were examined to determine the hepatoprotective effect of DLBS1433. Liver histopathology examination was also conducted in this study. Ethanol administration for 4 w was able to increase blood biochemical parameters which are the markers of liver function. Ethanol administration followed by DLBS1433-60 treatment showed lower blood biochemical parameters and better liver histopathology results compared to DLBS1433-90 treatment group. Based on the results of the present study, it can be concluded that DLBS1433-60 was considered as a potential hepatoprotective agent as shown by the results of blood biochemical parameters and liver histopathological examination. FLORENSIA NAILUFAR, HERY KRISTIANA AND RAYMOND R. TJANDRAWINATA hepatoprotective, liver, Phaleria macrocarpa, ethanol 313-319