10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 1 2017 (January - March) lessThan i greaterThan Jatropha platyphylla lessThan /i greaterThan is an endemic non-toxic Mexican specie from the Pacific coast, with high nutritional value and bioactive potential. The phenolics, tannins and antioxidant capacity of lessThan i greaterThan J. platyphylla lessThan /i greaterThan methanolic extracts and their effect on oxidative stress in macrophages were determined. The antioxidant potential of total phenolic extracts (TPE) and free tannin extracts (FTE) were evaluated on macrophage cells. The total phenolic content ranged from 487.82-1753.89 mg GAE 100 g lessThan sup greaterThan -1 lessThan /sup greaterThan , with the highest proportion of hydrolysable tannins (452.73-904.01 mg GAE 100 g lessThan sup greaterThan -1 lessThan /sup greaterThan ). lessThan i greaterThan In vitro lessThan /i greaterThan chemical methods showed values of 29-87% inhibition of radical DPPH and 68-844 mmolTEg lessThan sup greaterThan -1 lessThan /sup greaterThan for ORAC, and both methods revealed the influence of tannins content on antioxidant capacity. Besides, the TPE of bound phenolics from kernel and free phenolic from pulp showed 46 and 42% ROS inhibition, respectively. lessThan i greaterThan J. platyphylla lessThan /i greaterThan tannins showed a high antioxidant capacity, while TPE from kernel and phenolics from pulp showed a protective role of oxidative stress on macrophages cells. DULCE L. AMBRIZ-PEREZA, ROSALIO RAMOS-PAYANB, MIGUEL A. ANGULO-ESCALANTEA,JOSEFINA LEON-FELIXA , FRANCISCO DELGADO-VARGASB, J. BASILIO HEREDIAA. bound phenolics, hydrolysable tannins, macrophages, oxidative stress, tannins. 245-253