10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 1 2017 (January - March) We have developed a novel approach for the preparation of lessThan i greaterThan N lessThan /i greaterThan -[( lessThan i greaterThan Z lessThan /i greaterThan )-arylmethylidene] pyrrolidine-2-carboxamide using catalytic acetic acid through the reaction of different substituted benzaldehyde with lessThan i greaterThan L- lessThan /i greaterThan Prolinamide. These molecules were further cyclized with chloroacetylchloride under nucleophilic substitution reaction condition to finally afford 3-chloro-4-ary lessThan i greaterThan L- lessThan /i greaterThan 1-[(2 lessThan i greaterThan S lessThan /i greaterThan )-pyrrolidin-2-ylcarbonyl]azetidin-2-one. These synthesized compounds were further confirmed by IR, lessThan sup greaterThan 1 lessThan /sup greaterThan H NMR, and mass spectroscopy. All these final synthesized compounds have been screened for their biological activity against different strains for their antibacterial and antifungal activity. DARPAN B. PATEL AND VIKAS A. DESAI L-Prolinamide, Chloroacetylchloride, N-[(Z)-arylmethylidene] pyrrolidine-2-carboxamide, TEA. 167-173