10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 1 2017 (January - March) The study is to optimize the use of restricted antibiotics, to minimize the consequences of usage of Restricted Antibiotics (RA) & to determine the prevalence of resistant organisms. 316 patients receiving antibiotics in a tertiary care hospital in Kolkata, both restricted as well as non-restricted, were studied. The data was collected, analyzed for microbial & pharmacological impact analysis 316 patients under study, a total of 3218 antibiotics were dispensed, out of which834were restricted antibiotics (n=3218; 25.92%).The results showed that restricted antibiotic use consisted of 25.92%. According to the for Healthcare Epidemiology of the recommended use stands at 20%. In our study there is an increase of 5.92%. Recommended that health care institutions need robust infection control and antibiotic stewardship programs to prevent transmission of resistant bacteria and to decrease the selective pressure for resistance. DR(BRIG) ANIL PANDIT, DR.AMRUTA PANDIT AND DR. SAYAN SAHA Antibiotic Stewardship Program, Drug Formulary, Restricted Antibiotic usage 41-49