10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 3 2016 (July - September) Dyslipidemia in menopause is a known feature in women, which may lead to significant increase in the development of cardiovascular disease. The present study was aimed at comparing the lipid profile in premenopausal women with that of the postmenopausal women.Twenty-five apparently healthy premenopausal women and twenty-five apparently healthy postmenopausal women were recruited for the study. Fasting serum lipid profile were estimated using automatic analyser.There was significant difference in the lipid profile between the two groups. There was a significant increase in total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein in the postmenopausal group. Also there was a significant reduction of high density lipoprotein in the postmenopausal group.The elevated TC, LDL, TG, VLDL and the reduction in cardio-protective HDL is an indication that menopause is an independent risk factor for developing cardiovascular disease. A.TRISHALA, DR.V.VISHNU PRIYA, GAYATHIRI R. Lipid profile, premenopause, postmenopause, cardiovascular disease. 1109-1112