10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 3 2016 (July - September) Deterioration of β-cells in the pancreas is a crucial factor in the progression of Type 2 diabetes. Inhibition of enzyme DiPeptidyl Peptidase (DPP) -IV is considered as an anti-diabetic drug target which enhances the active Glucagon Like Peptide (GLP) -1 in the blood stream resulting in restoration of pancreatic β-cell mass and function. A number of plant and plant products are being used for the treatment of diabetes. Aloe vera is known to have anti-diabetic potential and the work carried out at our Centre by Noor et.al, 2008 had shown that oral feeding of Aloe vera extract to diabetic rats exhibited anti-diabetic potentials by restoring pancreatic islet mass and functions. In this study, we characterized the phytochemical constituents of Aloe vera extract and demonstrated that the Aloe vera extract inhibits DPP-IV with an IC50 value of 2.716 mg. We further discussed the implications of using such natural products in treating diabetic patients. C.PRASANNA RAJA, KRISHNAN VENKATARAMAN Aloe vera, phytochemical analysis, Diabetes, DPP-IV inhibition. 120-128