10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 3 2010 (July - September) Various substituted 3-amino-1-(2,4-dinitro phenyl)-5-[(5-substituted-1,3,4-oxadiazol-2-yl)amino]-1-Hpyrazole-4-carboxyamide and (5E)-5-[4-(dimethylamino) benzylidene]-3-(5-substituted-1,3,4oxadiazol-2-yl)-2-phenyl-3,5-di hydro-4H-imidazol-4-one containing different functional groups have been synthesised by using different aromatic aldehydes and semicarbazide. Different aldehydes and semicarbazide react to form semicarbazone. This was reacted with I2/KI solution to get corresponding 5-substituted-1,3,4-oxadiazol-2-amine. Half of the substituted oxadiazole condensed with Bis-s-methyl ethylene cyanoacetmide and finally with 2,4-dinitro phenyl hydrazine HCl in ethanol gives 3-amino-1-(2,4-dinitro phenyl)-5-[(5-substituted-1,3,4-oxadiazol-2-yl)amino]-1-H-pyrazole-4carboxyamide. Half of the substituted oxadiazole condensed with oxazolone in pyridine gives (5E)-5[4-(dimethylamino) benzylidene]-3-(5-substituted-1,3,4-oxadiazol-2-yl)-2-phenyl-3,5-di hydro-4Himidazol-4-one. The identity of compounds were confirmed on the basis of their spectral data. All the compounds have been screened for their anthelmintic activity.  Kalpesh Patel,Jayachandran E.,Ravi Shah,Vijaya Javali,Sreenivasa G. M. Semicarbazide, Oxadiazole, Pyrazole, Imidazole. -