10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 2 2016 (April - June) The present study was designed to investigate colon targeted and site specific drug release of Sulfasalazine enteric coated tablets was prepared. These tablets were formulated from F1-F8 by selecting time dependent and release retard natural polymers such as guar gum, pectin by combining with different concentrations HPMC(Methocel K100M) and carbopol(Carbopol® 974P NF Polymer) from wet granulation method. This HPMC (Methocel K100M) and carbopol (Carbopol® 974P NF Polymer) was included in this study to control the solubility of Guar gum and pectin premature drug release in the stomach and small intestine. There after the obtained tablets were coated by enteric polymer such as Eudragit-S 100 to retard the drug release at specified site colon by varying with different concentration as like 1, 3, 5, and7 %. This study also included all the evaluated precompression and post compressional parameters of sulfasalazine enteric coated tablets, with various release kinetic mechanism such as zero order, first order, higuchi plot and peppasmayer equations. From these all contributed results the formulation F7, it was pectin based containing Carbopol and enteric coated with the concentration Eudragit-S 100 of was optimized. M. KISHORE,B. VIJAYAKUMAR AND Y. NARASIMHAREDDY Sulfasalazine, Guar gum, Pectin, Eudragit-S 100, HPMC (Methocel K100M), Carbopol(Carbopol® 974P NF Polymer) and Colon. 90-97