10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 1 2016 (January - March) Hyponatremia is a very common electrolyte imbalance caused due to many etiologies, but is rarely due to hypopituitarism. A non-functional pituitary macro adenoma usually results in complaints like headaches and/or visual field defects might extend to blindness. But hyponatremia in macro adenoma is rare. Severe hyponatremia is a life-threatening emergency; hence an accurate diagnosis and a prompt initiation therapy are needed. We report a patient presenting with hyponatremia secondary to hypopituitarism along with hypothyroidism due to pituitary macro adenoma. DR. SAKTHI SELVA KUMAR , DR.M.V.BHARGAVI AND DR.S.PALANIANDAVAN Hyponatremia, hypopituitarism, pituitary apoplexy, syndrome of inappropriate secretion of ant diuretic hormone (SIADH) 419-424