10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 3 2010 (July - September) The present review of literature was done to check the influence of the main angiogenic factor vascular endothelial growth factor in the various physiological and pathological conditions like growth, development, tumor formation, arthritis etc. It was also seen that how VEGF are classified and produced as well as the mechanism of action. VEGF bind over the specific receptors and cause cascade of events of angiogenesis. So if the VEGF receptor antagonists are investigated they can block the VEGF receptor and prevent the process of angiogenesis which occurs in various chronic inflammations like solid tumor, rheumatic arthritis etc.  Yadu Nandan Dey,Neha Yadav,Mahvish Jamal,Ajoy Kumar Ghosh Angiogenesis, VEGF, Anti VEGF therapy, tumor, VEGF Receptor -