SYNTHESIS OF 2 – (1, 3 – SUBSTITUTED – 1 H- PYRAZOL-4-Y1) – 1H- BENZO (D) OXAZOLES BY USING AMMONIUM CHLORIDE; AS A MILD AND EFFICIENT CATALYST

10.22376/ijpbs.2019.10.1.p1-12

Volume 7 Issue 1 2016 (January - March) SYNTHESIS OF 2 – (1, 3 – SUBSTITUTED – 1 H- PYRAZOL-4-Y1) – 1H- BENZO (D) OXAZOLES BY USING AMMONIUM CHLORIDE; AS A MILD AND EFFICIENT CATALYST An efficient and simple procedure has been developed for the synthesis of 2- (1,3- substituted–1H- pyrazol–4-y1)–1H -benzo(d)oxazoles from the condensation of 3–Aryl-1- Phenyl –1H – pyrazole – 4- carabaldehyde with 2- aminophenol using ammonium chloride, which is a very inexpensive, metal free, readily available reagent. The target compounds were obtained in good yields under fairly mild reaction conditions at room temperature. CH.MADHU, S.HARIPRASAD, A.HYMAVATHI, K.RAMANJANEYULU, J.SANTHOSH KUMAR AND B.VENKATESWARA RAO Pyrazole aldehydes, 2-aminophenol, ammonium chloride, 1H- Benzo (d)oxazoles, Alzheimerâ€™s disease. 257-260