10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 1 2016 (January - March) Kanthari mulaku ( lessThan i greaterThan Capsicum frutescens lessThan /i greaterThan ), as it is known in Kerala, India is one of the most commonly used pepper species in cooking as well as folk medicine. The work was carried out to isolate, purify and test the efficacy of the antimicrobial peptides (AMPs) from this species.The purified peptide fraction when tested against lessThan i greaterThan E coli, Staphylococus aureus and Klebsiella pneumonia lessThan /i greaterThan by disk diffusion method showed inhibition zones of 3 to 12 mm range at 250 mg/ml concentration. The fungus lessThan i greaterThan Alternaria lessThan /i greaterThan and lessThan i greaterThan Colletotrichum lessThan /i greaterThan showed 100% inhibition of growth and Fusarium showed 66% inhibition of growth at 5 mg/ml concentration of fruit extract. The leaf extract however showed 75%, 12.5 % and 17.5% growth inhibition of lessThan i greaterThan Alternaria, Colletotrichum and Fusarium lessThan /i greaterThan at 5 mg/ml concentration. On the basis of these findings, it can be concluded that the purified antimicrobial peptide from lessThan i greaterThan C frutescens lessThan /i greaterThan could play strong roles in agriculture as a natural pesticide against various phytopathogens. SONA S DEV AND AKHIL VENU Antimicrobial peptides (AMPs), Kanthari mulaku, Capsicum frutescens 174-179