10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 1 2016 (January - March) Alcohol is an important substance with addictive potential. Alcohol is metabolised in the liver. Free radicals generated during the metabolism of alcohol is responsible for hepatic damage. Options available for treatment of alcohol induced liver disease was inadequate in modern medicine. lessThan i greaterThan Phyllanthus niruri lessThan /i greaterThan and lessThan i greaterThan Curcuma longa lessThan /i greaterThan have been shown to have hepatoprotective activity. Hence this study was undertaken to evaluate the effects of lessThan i greaterThan Phyllanthus niruri lessThan /i greaterThan and lessThan i greaterThan Curcuma longa lessThan /i greaterThan in combination to prevent alcohol induced hepatotoxicity. Evaluation was done by comapring the levels of liver enzymes, bilirubin, antioxidants, thiopentone induced sleeping time and liver hisotpathology in various groups of albino rats after administration of ethanol. Treatment with extracts of lessThan i greaterThan Phyllanthus niruri lessThan /i greaterThan and lessThan i greaterThan Curcuma longa lessThan /i greaterThan caused a significant reduction in liver enzymes, bilirubin levels and increase in antioxidants. The results of our study indicate that combination of lessThan i greaterThan Phyllanthus niruri lessThan /i greaterThan and lessThan i greaterThan Curcuma longa lessThan /i greaterThan possess significant hepatoprotective activity against alcohol induced liver damage. VINAY BS, SHALINI ADIGA, SHOBHA KAMATH, MOHANDAS RAO KG AND AVIN S Curcuma longa , hepatoprotection, antioxidants, liver enzymes 12-18