10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 3 2010 (July - September) In the present study total eight heavy metal resistant E. coli were isolated from sewage of industrial effluents from waste water treatment plant of Paonta Sahib H.P. India, against chromium, copper, nickel, cadmium. All the isolates exhibited high resistance to heavy metals with minimum inhibitory concentration (MIC) for heavy metals ranging from 50 µg/ml to 450 µg/ml. All isolates showed multiple tolerances to heavy metal and were multi antibiotic resistant. Heavy Metal Tolerance Test indicated maximum microbial tolerance of E. coli (Ec-7) to Chromium (400 µg/ml) and lowest to Copper (60 µg/ml).  lessThan br / greaterThan Virender Singh,P. K. Chauhan,Seema,Ankur Tyagi,Keshav Thakur,Anu Kumar,Vivek Kumar Antibiotics resistance, multiple tolerance, Heavy metal resistant bacteria (HMRB). -