International Journal of Pharma and Bio Sciences
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editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 6 Issue 4
2015 (October - December)
HEPATIC AND HEMATOLOGICAL ACTIVITIES OF HYDRO-ALCOHOLIC EXTRACT OF ERIOBOTRYA JAPONICA FRUITS IN SWISS ALBINO MICE
The hydro-alcoholic extract of fruits of lessThan i greaterThan Eriobotrya japonica lessThan /i greaterThan was evaluated for its toxicity on hepatic and hematological parameters in swiss albino mice. Animals of either sex were treated with different doses of the extract for its acute toxicity tests. The doses taken were 500,1000,1500,2000 mg/kg. In this LD lessThan sub greaterThan 50 lessThan /sub greaterThan was calculated. After finding the LD lessThan sub greaterThan 50 lessThan /sub greaterThan , optimum dose for sub-acute toxicity studies were taken. The effect of the plant extract on hepatic and hematological parameters were taken into consideration. The doses taken were 250 and 500 mg/kg b.w. Histopathology of liver and spleen were also done. The results shows that in acute toxicity studies, it showed that LD lessThan sub greaterThan 50 lessThan /sub greaterThan was 500mg/kg b.w and in sub-acute studies it showed variable biochemical parameters with no toxicity on liver and spleen.
SABEEHA SHAFI AND NAHIDA TABASSUM
Hydro-alcoholic extract, acute and sub-acute toxicity, Eriobotrya japonica.
643-654