10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) The present study aimed to investigate the possible prophylactic and therapeutic effects of hydro-alcoholic extract of lessThan i greaterThan Sapindus trifoliatus lessThan /i greaterThan on AD induced by AlCl lessThan sub greaterThan 3 lessThan /sub greaterThan in rats. In this study thirty adult Wistar albino rats were selected and were divided into 5 groups (six each). Group I, II, III, IV & V served as normal control, negative control, test group and standard control respectively. The rats were given treatment for 30 days and behavioural parameters were determined on 1 lessThan sup greaterThan st lessThan /sup greaterThan , 10 lessThan sup greaterThan th lessThan /sup greaterThan , 20 lessThan sup greaterThan th lessThan /sup greaterThan , &30 lessThan sup greaterThan th lessThan /sup greaterThan day of treatment. After day 30 lessThan sup greaterThan th lessThan /sup greaterThan rats were sacrificed and biochemical parameters (antioxidant levels & Acetylcholinesterase activity) were determined. This study indicated that lessThan i greaterThan Sapindus trifoliatus lessThan /i greaterThan when was used for treatment of AlCl lessThan sub greaterThan 3 lessThan /sub greaterThan induced AD, it improves the behavioural & biochemical parameters. The histopathological finding in hippocampus of brain tissue neuron appears less or more like normal one when compared to the negative control NIM BAHADUR DANGI, B.SREEDHAR NAIK, S.NAGARJUNA, ANIL SHRESTHA, HARI PRASAD SAPKOTA AND NABIN WAGLE Acetylcholine, Acetylcholinesterase, Sapindus trifoliatus, Morris water maze, passive avoidance test, Y-maze 456-471