10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) lessThan i greaterThan Lippia nodiflora Linn lessThan /i greaterThan a member of Verbenaceae family, is used in traditional and Unani system of medicine because of its antispasmodic, hair afflictions, anti-inflammatory, analgesic and antipyretic, antibacterial, anti lessThan i greaterThan Helicobacter pylori lessThan /i greaterThan activity, hypotensive activity, antinociceptive and antifungal. The purpose of the study is to check the efficacy of different fractions of whole plant lessThan i greaterThan Lippia nodiflora lessThan /i greaterThan on uninephrectomized DOCA-salt hypertensive rats. Dried and powdered whole plant was extracted with chloroform, ethyl acetate, methanol and water; and administered in doses of 500 mg/Kg p.o. Preliminary phytochemical analysis of plant reveals presence of flavonoids, alkaloids, triterpenes, glycosides and sterols. Data was analysed by one way analysis of variance (ANOVA) followed by Tukey's test. Among all these extracts, methanolic extract was found to be effective as it reduced the systolic blood pressure significantly. We have also checked the creatinine level as a renal marker; histopathology of kidney also confirmed the biochemical findings. This study supports the antihypertensive role and renoprotective effect of methanolic fractions. REKHA GADHVI , M. N. REDDY AND SHRIKANT JOSHI Lippia nodiflora, Uninephrectomized, DOCA-salt, antihypertensive 392-399