10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) lessThan i greaterThan Cleome icosandra, Rosa damascena lessThan /i greaterThan and lessThan i greaterThan Cyperus scariosus lessThan /i greaterThan used extensively in Unani system of medicine to combat various ailments. Extracts of these plants were also noted with antioxidant potential. However, evaluation of bioactive composition of active fractions is essential for its future exploitation as a health-promoting natural product. IC lessThan sub greaterThan 50 lessThan /sub greaterThan values of lessThan i greaterThan n lessThan /i greaterThan -butanol and chloroform fractions derived from crude extracts and scavenging of DPPH, ABTS, lessThan sup greaterThan • lessThan /sup greaterThan OH, O lessThan sub greaterThan 2 lessThan /sub greaterThan lessThan sup greaterThan • lessThan /sup greaterThan lessThan sup greaterThan − lessThan /sup greaterThan , ONOO lessThan sup greaterThan − lessThan /sup greaterThan and lessThan sup greaterThan • lessThan /sup greaterThan NO, were determined. These active fractions exhibited oxidative DNA damage preventive activity and significant FRAP. No cytotoxicity against U937/PBMC cell lines was noted. Total phenolic and flavonoid content of active fractions was measured. Various phytochemicals viz. quercetin, quercetin-3-o-rutinoside, quercetin-3-o-glucoside, linoleic acid, oleanolic acid, sitosterol, cleomiscosin A and C etc. were identified by ESI-MS analysis of these active fractions and contributing towards the natural antioxidant activity of lessThan i greaterThan C. icosandra, R. damascena lessThan /i greaterThan and lessThan i greaterThan C. scariosus lessThan /i greaterThan , revealed their potential as a functional food. MEHAR D. KALIM, D. DUTTA, P. DAS, AND S. CHATTOPADHYAY Unani plants, Antioxidant potential, Oxidative DNA damage, Phenolics, Flavonoids 330-342