10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) Levobupivacaine , the pure S enantiomer of bupivacaine has emerged as a safe local anaesthetic than its racemic counterpart. Dexmedetomidine the novel selective alpha2 adrenergic agonist has several advantages when given through epidural route as an adjuvant. To compare plain 0.5% Levobupivacaine with Dexmedetomidine and 0.5% levobupivacaine epidurally for the time of onset of sensory blockade and its duration. 60 patients undergoing infraumblical and lower limb surgeries were randomized to two groups. Group A(n=30) received only Levobupivacaine 0.5% 20 ml epidurally. Group B(n=30) received 50 mcg of dexmedetomedine with Levobupivacaine 0.5% 20 ml epidurally. The time of onset of sensory blockade, maximum height of sensory blockade and duration of blockade were noted. Statistical work done by student t test and chi-square test and p lessThan 0.05% were taken to be significant. Dexmedetomidine fastens the onset of sensory blockade and the duration of blockade without any significant adverse effects. : We conclude that Dexmedetomidine can be used as an adjuvant to Levobupivacaine which fastens the onset and prolong the duration of sensory blockade. DR.ARUN POTHAN RAJ.V AND DR.NIRANJAN KUMAR Levobupivacaine, Dexmedetomidine, Sensory blockade. 1264-1269