10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) The parts of lessThan i greaterThan Adenium obesum lessThan /i greaterThan (Desert rose) plant has been known to possess a wide range of biological activity consisting stems and roots. The purpose of present study was to ensure the presence of antibacterial activity in aqueous and alcoholic extracts of leaves of lessThan i greaterThan Adenium obesum. lessThan /i greaterThan Antibacterial sensitivity test was done against Gram positive bacteria ( lessThan i greaterThan Bacillus amyloliquefaciens lessThan /i greaterThan and lessThan i greaterThan Staphylococcus aureus) lessThan /i greaterThan and Gram negative bacteria ( lessThan i greaterThan Pseudomonas aeruginosa lessThan /i greaterThan and lessThan i greaterThan Escherichia coli lessThan /i greaterThan ) by Agar well diffusion method. Inhibition length was calculated and found to be maximum in alcoholic extract. Phytochemical screening was done in order to check the presence of active components in leaves of lessThan i greaterThan Adenium obesum lessThan /i greaterThan . Result showed that methanolic extract has effective antibacterial activity against Gram positive bacteria and ineffective against Gram negative bacteria. The study suggest that leaves of lessThan i greaterThan Adenium obesum lessThan /i greaterThan (Desert rose) plant can be used as an antimicrobial agent and expected that leaves of lessThan i greaterThan Adenium obesum lessThan /i greaterThan may be used as therapeutic agents for various diseases. SHARMA YASH, NAGAR ANSHITA AND SHUKLA SUSMITA Adenium obesum, Antibacterial sensitive test, Phytochemical screening 85-92