International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 6 Issue 3
2015 (July - September)
ANALYSIS OF DNA REPAIR GENETIC POLYMORPHISM IN BREAST CANCER POPULATION
The aim of the present study is to analyze the variations in DNA repair genetic pathways in Breast Cancer. The study carried out in three groups, 50 Participants in each group. Females newly diagnosed for breast cancer, females at high risk for breast cancer, and females with normal health are included for the study. The polymorphisms namely Arg 194 Trp, Thr 241 Met, Arg 415 Gln, Asp 1104 His are investigated using their peripheral blood. The three polymorphisms Arg 194 Trp, Arg 415 Gln, Asp 1104 His are presented to be significantly associated with breast cancer in their heterozygous mutant type with P- Value - 0.01, 0.009, and 0.0001 respectively. Females with breast cancer and those categorised as high risk females presented similar polymorphism status. DNA repair genes are regions of DNA which repair the emergent damage rapidly and effectively. Variations in these genes increase the risk of occurrence of breast cancer.
LAVANYA.J, DR. VIJAYAKUMAR. J, DR. N. SUDHAKAR AND DR. S. PRATHAP
Breast Cancer, High Risk Females, Polymorphism, and DNA repair genes.
966-973