10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) Immunotherapy is a novel approach to combat cytokine mediated diseases. Immunomodulatory drugs are known to play a vital role in altering the cytokine profile and the outcome of disese. Several medicinal plants were shown to possess immune modulatory properties. One of the popular Indian medicinal plant known as lessThan i greaterThan Pongamia pinnata lessThan /i greaterThan ( lessThan i greaterThan P. pinnata lessThan /i greaterThan ) has been extensively studied for its bioactive properties. We have reported in our previous study for lessThan i greaterThan P. pinnata's lessThan /i greaterThan immune modulatory properties however this study extended to investigate further its immunomodulatory property of bark extracts. In this study it was found that bark extracts of lessThan i greaterThan P. pinnata lessThan /i greaterThan profoundly increased the human IFN- γ and IL-10 which also support our previous findings with seeds extracts. These findings strongly suggest that lessThan i greaterThan P. pinnata's lessThan /i greaterThan immunomodulatory role on human immune cells. MANIKANNAN MATHAIYAN AND DINESH SUBRAMANIYAM PBMCs, Leukotriene B4, Cytokines, Pongamia pinnata, Immunotherapy 929-936