10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) Antidiabetic effect of plants and their active principles can be assessed lessThan i greaterThan in vitro lessThan /i greaterThan using a variety of biological test systems. They play a major role in evaluation of antidiabetic properties as an initial screening tool prior to lessThan i greaterThan in vivo lessThan /i greaterThan studies. The present review focuses on lessThan i greaterThan in vitro lessThan /i greaterThan assays that are available to study potential antidiabetic activity of plant extracts and their active constituents. It is evident that these plant extract and compounds derived from them are capable of lowering blood glucose level through different mechanism of action. This has attracted a great deal of research interest in exploring natural sources. lessThan i greaterThan In vitro lessThan /i greaterThan assay provides a basic platform for accusing these plant extracts and help us understand various mechanisms that would alleviate hyperglycaemia in diabetes. DORIN DSOUZA AND N. LAKSHMIDEVI In vitro, α-amylase, α-glucosidase, Glucose uptake, Cell lines, Glut 4, PPAR- γ 732-741