10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) Diabetes mellitus is a chronic endocrine disorder that affects the metabolism of carbohydrates due to absolute or relative deficiency of insulin. In recent years, there is a sharp increase in the incidence and prevalence of diabetes mellitus which demands an effective and immediate approach to cure it. One of the anti-diabetic therapeutic approaches is to reduce the post prandial glucose level in blood by the inhibition of the intestinal digestive enzymes, such as alpha-amylase and alpha-glucosidase. The objective of the present work was to analyze the phytochemicals qualitatively and to evaluate the anti-diabetic activity of different polar and non-polar extract of lessThan i greaterThan Cardiospermum halicacabum lessThan /i greaterThan L. lessThan i greaterThan in vitro lessThan /i greaterThan conditions. Different concentrations of extracts were used for the evaluation of alpha-amylase and alpha-glucosidase inhibition activity. The assay results suggest that all the extract of lessThan i greaterThan C. halicacabum lessThan /i greaterThan exhibit dose-dependent increase in inhibitory activity on α-amylase and α-glucosidase enzymes due to the presence of phytoconstituents. This infers that lessThan i greaterThan C. halicacabum lessThan /i greaterThan can be used as a potent herbal drug for the treatment of diabetic patients. MERINA PAUL DAS, Y. YASMINE AND P.VENNILA DEVI Cardiospermum halicacabum. L, Phytochemicals, Anti-diabetic, α-amylase, α-glucosidase. 711-719