10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 3 2010 (July - September) Formulation of potent drug molecules as dosage form still draws continuous interest and challenges against its optimization towards pharmacokinetics parameters like absorption, bioavailability, onset of action, duration of action Besides it has been proved that by increasing gastric retention time will increase the drug absorption effectively..Lamivudine is an potential anti-HIV agent, used for the long term treatment of HIV-1 infection.It is approved by the U.S Food and Drug Administration (FDA). The dissolution characteristics of optimized multi unit formulation MF8 is compared with that of the pure drug and Marketed formulation (EPIVIR). Compatibility among the drug and optimized polymer i.e., Geleol Pastilles was assessed by performing IR spectroscopy studies Characteristics with the aid of Geleol Pastilles as polymer. , very promising lessThan i greaterThan in vitro lessThan /i greaterThan results were observed with multi unit floating formulations of Lamivudine, further there is a scope to conduct the bioavailability studies in human volunteers to know the exact pharmacokinetics of the developed multi unit GFDDS of Lamivudine. Varun Dasari,Bahlul Z. Awen,Babu Rao Chandu,Khagga Mukkanti Multiunit, Single unit,non effervescent,Buoyancy. -