10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) Parkinson disease (PD) is a progressive neurodegenerative disorder which leads to motor impairment. Sesamol (SA) is a potent antioxidant, present in sesame oil and Folic acid (FA) involved in dopamine synthesis was combined together in this study and their impact on 6-OHDA induced animals was to be studied. The gene and protein expression of DJ-1, LRRK-2 and parkin were analysed by RT-PCR and western blotting. The level of dopamine was estimated by fluorimetric analysis. The presence of tyrosine hydroxylase positive (TH lessThan sup greaterThan + lessThan /sup greaterThan ) neurons was analysed by immunohistochemistry. On comparison with L-dopa, the SA and FA treated animals shows a protective effect on neurons toxicated with 6-OHDA. SA and FA suppress LRRK-2 and trigger the DJ-1 and parkin synthesis by regulating their respective gene. SA and FA have regulated dopamine level and TH lessThan sup greaterThan + lessThan /sup greaterThan neurons. Thus SA and FA may serve as a novel combined drug for treatment of PD. KHADIRA SEREEN A AND VIJAYALAKSHMI K Parkinson’s disease, Sesamol, Folic acid, DJ-1, LRRK-2, parkin 346-354