10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) Isonicotinoyl and nicotinoyl hydrazones bearing pyridine moiety have been synthesized by simple condensation reaction between carbonyl compounds(1-3) viz. 2-formyl pyridine, 2-acetylpyridine, 2- benzoylpyridine and isonicotinic acid hydrazide (4)/nicotinic acid hydrazide(5). All the hydrazones are thoroughly characterized by IR, lessThan sup greaterThan 1 lessThan /sup greaterThan H- NMR and mass spectral data. Syntheses of these compounds are further confirmed by mass spectrometry. All the compounds (6-11) were screened for their anti-bacterial activities against lessThan i greaterThan Staphylococcus aureus, lessThan /i greaterThan lessThan i greaterThan Bacillus subtilis, Escherichia coli lessThan /i greaterThan and lessThan i greaterThan Salmonella typhi lessThan /i greaterThan . Isonicotinoyl hydrazones show more antibacterial activity than the corresponding nicotinoyl hydrazones. Substituent groups -H, -CH lessThan sub greaterThan 3 lessThan /sub greaterThan and C lessThan sub greaterThan 6 lessThan /sub greaterThan H lessThan sub greaterThan 5 lessThan /sub greaterThan  groups of azomethine carbon are varied. The hydrazones having a methyl group attached to azomethine carbon atom show more pronounced activity. B. MOKSHARAGNI, KANDERI DILEEP KUMAR, S. CHANDRASEKHAR AND K. HUSSAIN REDDY Synthesis, characterization, isonicotinoyl and nicotinoylhydrazones, antibacterial activity. 11-18