10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) Western Thar Desert is rich in varieties of plants. lessThan i greaterThan Prosopis cineraria lessThan /i greaterThan , one of boon plants of Western Rajasthan give valuable natural possessions to the people. It belongs to member of a family Leguminosae, is a tree that is mostly found in the Thar Desert of Western Rajasthan. It is native to arid portions of Western and South Asia. lessThan i greaterThan Prosopis cineraria lessThan /i greaterThan is one of the exemplary attempts were made to isolate successive extracts with methanol & chloroform of lessThan i greaterThan selected lessThan /i greaterThan valued plant in the native System of Medicine. Therefore, in the present investigation lessThan i greaterThan is P. cineraria(Leaf ) lessThan /i greaterThan and Antimicrobial activity were performed against selected bacterial species. Methanolic extract of lessThan i greaterThan P. cineraria lessThan /i greaterThan leaf extract shows maximum inhibition zone against lessThan i greaterThan Proteus vulgaris lessThan /i greaterThan (AI=2.5 for 10mg/disc) and lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan (AI= 2.09 for 5mg/disc). Therefore lessThan i greaterThan Prosopis cineraria lessThan /i greaterThan can be used for bioactivity guided fractionation to work as potential source of therapeutics and /or antibiotics in future for curing of various ailments against multi drug resistant bacteria. Further, this weed will work as novel targets for antibiotics in future. ADNAN KHOKAR AND EKTA MENGHANI Prosopis cineraria (L.) Druce, Antimicrobial activity. 222-229