10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 3 2015 (July - September) The present study aims to investigate the anti-hypercholesterolemic effects of sesame oil in a high-fat fed rat's model for ninety days. Black sesame oil (BSO) rich in linoleic acid ( lessThan i greaterThan omega lessThan /i greaterThan 6 and 9) was tested to evaluate prophylactic, protective and therapeutic hypolipidemic effects in comparison with evening primrose oil (rich in linoleic acid and γ- linolenic acid, lessThan i greaterThan omega lessThan /i greaterThan 6) and with olive oil (rich in oleic acid and lessThan i greaterThan omega lessThan /i greaterThan 9). The serum total lipid (TL), total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), risk ratio (RR), and liver function enzyme activities; aspartate and alanine aminotransferases (AST and ALT) as well as alkaline phosphatase (ALP) were investigated. Hypercholesterolemic feeding rats resulted in significant elevation of TC, TG, LDL-C, HDL-C, AST and ALT as compared to the rats feeding normal diet (𝑃 FAROUK K. EL-BAZ , ZEINAB A. SALAMA, HANAN F. ALY AND HANAN A. TAIE1 Sesamum indicum L.; antihyperlipidemic; liver function; kidney function; liver fatty acids and hyperlipidemia 177-189