10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 2 2015 (April - June) In this study the biodegradative activity of lessThan i greaterThan Pleurotus ostreatus lessThan /i greaterThan was tested against a natural waste (Coir) along with a synthetic polymer waste (Nylon 6). Lignin modifying enzymes such as laccase, lignin peroxidase and manganese peroxidase activity were tested for coir and nylon 6 degradation in solid substrate fermentation. Enumeration of degradation with loss of weight, lignin degradation assay (Klason lignin method ASTM D- 1106) and functional group changes monitored by FTIR spectroscopy. It has been observed as lessThan i greaterThan Pleurotus ostreatus lessThan /i greaterThan degrades lignin present in coir from 30.6% to 6.2% within 30 days. Nylon 6 also reported 36% degradation. FT IR analysis of treated coir concludes changes in functional groups and IR bands converted from strong to weak represented degradation. ARUN KUMAR. J, GOPINATH. LAND SHANTHA PREMA RAJ Pleurotus ostreatus, Coir, Lignin, Laccase, Lignin peroxidase and Nylon 6. 1454-1461