10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 2 2015 (April - June) Mupirocin is a topical antimicrobial agent utilized in treatment of methicillin resistant lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan . Mupirocin resistance in lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan is increasingly being reported in many parts of the world in the context of its widespread use. The objectives of this study were to determine the susceptibility of methicillin resistant lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan clinical isolates to mupirocin to assess the prevalence of low and high level of mupirocin resistance among them, to detect their resistance to other antimicrobials and also to correlate their mupirocin susceptibility with resistance to other antimicrobials. Methicillin resistant lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan isolates were tested by disc diffusion method using 5µg and 200µg mupirocin discs respectively to determine low and high level resistance to mupirocin. Susceptibility testing to other antimicrobials, including erythromycin, gentamicin, co-trimoxazole, ciprofloxacin, tetracycline, clindamycin, chloramphenicol, vancomycin and linezolid were also done. 54.12% lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan isolates were found as methicillin resistant, of them 14.13% and 4.35% showed low and high level resistance to mupirocin respectively. No resistance were detected to vancomycin and linezolid. Mupirocin resistant isolates showed more susceptibility to clindamycin and tetracycline as compared to mupirocin sensitive methicillin resistant lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan isolates. TANUSHREE BISWAS AND MUNMUN DAS (SARKAR) Staphylococcus aureus, Methicilline Resistance, Mupirocin 1400-1407