Pharmacological Basis for the Continual Use of the Root of Senna Siamea in Traditional Medicine

10.22376/ijpbs.2019.10.1.p1-12

Volume 1 Issue 3 2010 (July - September) Pharmacological Basis for the Continual Use of the Root of Senna Siamea in Traditional Medicine The sub-acute toxicity of the aqueous extract of the root of lessThan i greaterThan Senna siamea lessThan /i greaterThan was studied in rats. Oral administration of lessThan i greaterThan S. siame lessThan /i greaterThan for 28 days produced neither mortality nor changes in behavior or any physiological activities. Results obtained showed that the extract insignificantly (p greaterThan 0.05) affected the mean body and organ weight of wistar rats. Hematological parameters (PCV, Hb, WBC. and RBC) and biochemical parameters, (Serum creatinine, serum urea, sodium, potassium ions, alkaline phosphatase (ALP), alanine aminotransaminase (ALAT), aspartate aminotransaminase (ASAT)) were not affected by the extract. Histological studies of vital organs did not show any statistical significant difference between the same organs. These results may explain the continual use of lessThan i greaterThan S. siamea lessThan /i greaterThan in folk medicine. Otimenyin S. O. Kolawole,J. A.,M. Nwosu Senna siamea, hematological, biochemical parameter, body and organs weight, acute toxicity study -