10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 2 2015 (April - June) Extract of lessThan i greaterThan Aloe vera lessThan /i greaterThan leaves has been used for treatment of various diseases and disorders in ayurveda and unani medicine. Modulatory effect of lessThan i greaterThan Aloe vera lessThan /i greaterThan against radiation and cadmium induced changes in terms of histological alterations in testis has been studied in present investigation. For this purpose mouse exposed to 7.0 Gy radiation showed radiation induced sickness, including marked changes in histology of testis. The lessThan i greaterThan Aloe vera lessThan /i greaterThan leaf extract was given orally at a dose of 1000 mg/kg body wt/animal/day for five consecutive days prior to irradiation. The radiation dose reduction factor was 1.65. lessThan i greaterThan Aloe vera lessThan /i greaterThan pre treatment significantly prevents radiation and cadmium induced histopathological changes in cells. The study suggested that lessThan i greaterThan Aloe vera lessThan /i greaterThan extract has exerted significant radioprotective effects on testis. It is well known that lessThan i greaterThan Aloe lessThan /i greaterThan is an essential component of antioxidant defense system with participation at multiple cellular levels. lessThan i greaterThan Aloe lessThan /i greaterThan has a protective effect on histological damage by maintaining membrane integrity due to its direct action of free radicals. It can be concluded that lessThan i greaterThan Aloe lessThan /i greaterThan has a protective role against cytotoxicity induced by radiation and cadmium in the testes of Swiss albino mice. PUROHIT RK, BHATI SL, PURKHARAM, ISRAN R, AGARWAL M AND CHAKRAWARTI A Aloe vera, Swiss albino mice, Radiation, Cadmium, Testes. 821-829