10.22376/ijpbs.2019.10.1.p1-12 Volume 6 Issue 2 2015 (April - June) The present study is to screen the antibacterial and antioxidant activity of the plant three sided lessThan i greaterThan Cissus quadrangularis lessThan /i greaterThan (Muppirandai) and to perform lessThan i greaterThan in silico lessThan /i greaterThan analysis for the compounds identified through GC-MS analysis. Ethanolic extract of the plant was prepared by soxhlet extraction. Antibacterial activity was tested against lessThan i greaterThan Bacillus cereus, Staphylococcus aureus, Escherichia coli lessThan /i greaterThan and lessThan i greaterThan Salmonella typhi lessThan /i greaterThan , among which the extract was more effective against lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan . Phytochemical analysis proved the presence of constituents such as flavonoids, carbohydrates, tannins, phenols, saponins, proteins and amino acids. Antioxidant potential of the plant was evaluated by DPPH assay. Nine compounds were identified through GC-MS analysis and were subjected to docking study, which was performed with LuxS receptor 1JVI using Autodock 4.2, Cygwin and Discovery studio. These compounds exhibited high negative binding energy and a maximum of three hydrogen bonds were formed between the ligand Cholestane-3, 6, 7-triol, (3à, 5à, 6à, 7à) and the receptor. J. HELAN CHANDRA AND SUHASHINI. R Ethanol, phytochemical, GC-MS, ligand, receptor, docking. 657-665